The Advancing Toxicokinetics for Efficient and Robust Chemical Evaluations Applications RFA is now open through Sept. 24, 2019.
Open Date: July 25, 2019 Close Date: September 24, 2019
Background: The U.S. Environmental Protection Agency (EPA) announces the Advancing Toxicokinetics for Efficient and Robust Chemical Evaluations RFA.
Understanding chemical disposition in the human body is useful in health assessments where linkages between external exposure, internal dose and likelihood of health effects are important. Toxicokinetics (TK) describe the absorption, distribution, metabolism, and excretion of a chemical and its metabolites by the body. Such information has been used to interpret dose-response relationships obtained from whole animal testing. When combined with high-throughput in vitro screening data that identify concentrations causing biological perturbations, TK information has led to major advances in the development and acceptance of New Approach Methodologies (NAMs) for chemical risk assessment.
The U.S. EPA, as part of its Science to Achieve Results (STAR) program, is seeking applications proposing to advance the development of chemical toxicokinetic tools and approaches for broader applicability to chemical evaluations. An emphasis on their application within new approach methodology (NAM) frameworks is sought. The ability to quantitatively link in vitro-derived biological perturbations to in vivo doses, or in vitro to in vivo extrapolation (IVIVE), has demonstrated the value of NAMs in efficiently screening chemicals.
This RFA seeks research that develops new and innovative approaches, assays and/or datasets to expand on currently available chemical TK information for use in chemical evaluations. Development of methods and approaches that increase throughput and predictivity while reducing uncertainty of current IVIVE approaches for ultimate application in a broader NAM framework are priority needs. The proposed research should provide the best available science needed to address them. The research also will improve the scientific foundation for environmental policy and decision-making related to chemical exposure and risk.
Researchers will address gaps in the availability of high throughput assays for elucidating chemical toxicokinetics. The research will ultimately support efforts to protect citizens from the effects of chemical pollutants. Any new method should include some degree of evaluation, characterizing predictive ability and domain of applicability.
Research efforts should fall in one of two broad categories:
New in vitro measures of in vivo toxicokinetics, and
New in vitro methods or techniques that do not require analytical chemistry to assess chemical levels in TK assays. Analytical chemistry method development is often a significant bottleneck of the currently available assays.
This RFA is supported by EPA’s Chemical Safety for Sustainable Research Program (CSS), which seeks to improve the safe production, use, and disposal of chemicals to protect human health and the environment.