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NSF Ideas Lab: Advancing Cell-Free Systems for an Extensive Range of Use-Inspired Applications - Pre-Applications Due 05/17; Full Applications Due 09/20

Opportunity Title:

Ideas Lab: Advancing Cell-Free Systems Toward Increased Range of Use-Inspired Applications



National Science Foundation (NSF)


Opportunity Number:




The Advancing Cell-Free Systems Toward Increased Range of Use-Inspired Applications (CFIRE) initiative will accelerate the adoption of cell-free systems, enable new applications of this technology and contribute to the growth of the U.S. bioeconomy.

CFIRE aims to:

  • Reduce the cost of cell-free systems;

  • Increase the range and capabilities of cell-free systems; and

  • Develop and demonstrate cost-effective use-inspired applications.

CFIRE seeks significant breakthroughs that will accelerate the adoption of cell-free systems by:

(a) Demonstrating the feasibility and advantages of cell-free systems through use-inspired applications with specific emphasis on applications beyond human therapeutics;

(b) Creating infrastructure components, such as tools, protocols, kits, datasets, and characterization services that can readily be accessed by third parties; and

(c) Investing in workforce components focused on the training of translational talent with the skills and passion to engage in use-driven cell-free applications.


CFIRE will use the Ideas Lab process (see PAPPG Chapter II.F.6), starting with an intensive meeting that brings together multiple diverse perspectives. The primary objectives of this Ideas Lab workshop will be to: identify specific opportunities to significantly reduce the cost of cell-free systems; establish acceptable standards for the fidelity and reproducibility; expand the range of capabilities in order to facilitate broader adoption of the technology; and identify and prioritize use-driven applications beyond human therapeutics.


  • Institutions of Higher Education (IHEs)

  • For-profit organizations

  • Tribal Nations

  • Foreign organizations

  • Other Federal Agencies and Federally Funded Research and Development Centers (FFRDCs)

  • Non-profit, non-academic organizations - Independent museums, observatories, research laboratories, professional societies


Award Details:

Total Amount Available:



Maximum Award:




Pre-Applications Due May 17, 2024

Applications Due September 20, 2024



Grant Management Associates has years of experience with opportunities like this one. Contact us today for a consultation.

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